A Genetic Strategy for Stochastic Gene Activation with Regulated Sparseness (STARS)
نویسندگان
چکیده
منابع مشابه
A Genetic Strategy for Stochastic Gene Activation with Regulated Sparseness (STARS)
It remains a challenge to establish a straightforward genetic approach for controlling the probability of gene activation or knockout at a desired level. Here, we developed a method termed STARS: stochastic gene activation with genetically regulated sparseness. The stochastic expression was achieved by two cross-linked, mutually-exclusive Cre-mediated recombinations. The stochastic level was fu...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2009
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0004200